Therapeutic Targeting of the Endoplasmic Reticulum in Alzheimers Disease
نویسندگان
چکیده
منابع مشابه
Endoplasmic reticulum stress in disease: mechanisms and therapeutic opportunities.
Various stresses, which impair ER (endoplasmic reticulum) function, lead to an accumulation of unfolded or misfolded proteins. ER stress triggers many rescuer responses, including a UPR (unfolded protein response). Increasing evidence has suggested that ER stress is involved in neurodegenerative diseases (Alzheimer's disease, Parkinson's disease and cerebral ischaemic insults), cancer, obesity ...
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Cardiovascular disease constitutes a major and increasing health burden in developed countries. Although treatments have progressed, the development of novel treatments for patients with cardiovascular diseases remains a major research goal. The endoplasmic reticulum (ER) is the cellular organelle in which protein folding, calcium homeostasis, and lipid biosynthesis occur. Stimuli such as oxida...
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The targeting of proteins to the endoplasmic reticulum (ER) membrane is the first step in the secretory pathway through which proteins are transported to the outside of the cell, the plasma membrane, and the luminal spaces and membranes of the endomembrane system. Proteins that undergo this targeting event carry a stretch of hydrophobic amino acids, usually at the amino terminus, that constitut...
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GRP78 (glucose-regulated protein of 78 kDa) is traditionally regarded as a major ER (endoplasmic reticulum) chaperone facilitating protein folding and assembly, protein quality control, Ca(2+) binding and regulating ER stress signalling. It is a potent anti-apoptotic protein and plays a critical role in tumour cell survival, tumour progression and angiogenesis, metastasis and resistance to ther...
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Background: Defects in endoplasmic reticulum homeostasis are common occurrences in different diseases, such as diabetes, in which the function of endoplasmic reticulum is disrupted. It is now well established that ion channels of endoplasmic reticulum membrane have a critical role in endoplasmic reticulum luminal homeostasis. Our previous studies showed the presence of an ATP-sensitive cationic...
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ژورنال
عنوان ژورنال: Current Alzheimer Research
سال: 2012
ISSN: 1567-2050
DOI: 10.2174/156720512799015055